Not without a project currently.
Is there a reason you can't use a project? In case it helps, the projects aren't static, and by "Including All Objects" in each of the groups you describe (in both but different, in source but not target) and select "Exclude All Objects" for in target but not source, then any new objects in the first groups would be included for future deployments, and excluded for the final group.
Please do let us know if this would work.
Also we've started taking feature requests on UserVoice so that people can vote and comment on each other's ideas, feel free to add this request and others there too:
http://redgate.uservoice.com/forums/174 ... ilters/top