I'm having a similar issue. I'm trying to profile on my server (DB connection obscures other issues if I debug from my development machine). I built a debug version to make sure I had up-to-date PDBs, started the web application with Debug="true", but it still can't find source code. I uploaded a copy of the source code to the server, but can't find a way to tell ANTS where it is. I tried everything I could from the missing results and PDB problems posts.