Your Internet Explorer may be running in protected mode, making your application start and quickly terminate. From our "Troubleshooting IIS Profiling" article (http://www.red-gate.com/supportcenter/C ... _start_iis
To prevent this error:
•If possible, turn off Protected Mode in Internet Explorer before starting a profiling session.
•If you need to use Protected Mode, add localhost to the list of trusted sites, and try to profile your application again. For instructions on adding a site to Internet Explorer's Trusted Sites list, see Security zones: adding or removing websites (Microsoft).
I hope that helps!